Achievement

IGERT trainee Joshua Campbell (graduated May, 2012) in Campbell JD, Spira A, Lenburg ME. Respirology. 2011,16(3):407-18. Gene expression microarrays are high throughput technologies that simultaneously measure the expression levels of thousands of genes within a biological sample. Examining gene expression in samples from patients with pulmonary disease can elucidate molecular mechanisms responsible for disease pathogenesis or uncover novel molecular subtypes within a disease. Biomarkers can be developed from gene expression data that can aid clinicians in diagnosing disease or can guide clinicians in tailoring therapeutic strategies to individual patients. To demonstrate the applications of gene expression microarray technology, this paper reviews several studies in pulmonary disease that utilize gene expression profiling techniques to gain biological insights into disease or to develop clinically relevant biomarkers for disease management.