Achievement

IGERT trainee Chris Jacobs in Jacobs, C. Segr̀ D, Organizing principles in genetic interaction networks, O. S. Soyer (Ed.), Advances in Experimental Medicine and Biology: Evolutionary and Systems Biology, Springer (in press). Genetic modifications underlie several important aspects of biology. It is through genetic modifications that organisms evolve. Genetic modifications are used in genetic engineering and synthetic biology to redesign and optimize cells for practical applications. It is also often through targeted or systematic genetic modifications that biologists have uncovered many aspects of how biological systems work. While individual genetic perturbations are important by themselves, there is something fundamental about how genetic perturbations affect a system when performed in concert. In this book chapter, these themes are discussed.